P. Naresh Babu1, M. Gobinath2, M. Lakshmidevi*1, SK. Karimulla1, Ramesh Dhani2
1Department of Pharmacology, Ratnam Institute of Pharmacy, Pidathapolur, Muthukur, SPSR Nellore, A.P, India.
2Department of Pharmaceutical Chemistry, Ratnam Institute of Pharmacy, Pidathapolur, Muthukur, Nellore, A.P, India.
A B S T R A C T
Ailanthus glandulosa (Linn). Planch has been used from long time in traditional medicine. The main objective of the work was to evaluate the anticonvulsant activity of Ailanthus glandulosa. The anticonvulsant activity of ethanolic extract of Ailanthus glandulosa leaves was evaluated using Pentylentetrazole [PTZ] as induced convulsions in mice and maximal electric shock (MES) induced convulsions and lithium-pilocarpine induced status epilepticus in mice. Preliminary phytochemical investigation of the ethanolic extract of Ailanthus glandulosa intrigifolia leaves are the presence of glycosides, saponins, quassinoids, steroid, amino acids, tannins, carbohydrates and flavanoids. The ethanolic extract (100 mg/kg and 300 mg/kg) delayed onset of [PTZ] as induced convulsions and also prolonged the onset of clonic convulsions in mice. The extract are protect the mice from (MES) induced convulsions. The extract also protected mice against seizures induced by lithium –pilocarpine. In lithium –pilocarpine models the ethanolic extract (100 mg/kg and 300 mg/kg) delayed the latency to rearing with forelimb clonus significantly. The results indicate that ethanol extract contained such phytochemical compounds which are active in case of Pentylentetrazole (PTZ) and Maximal electroshock (MES) and lithium pilocarpine induced status epilepticus, which support the ethno medicinal application of the plant as an anticonvulsant agent.
Keywords: Ailanthus glandulosa, Pentylentetrazole [PTZ], flavanoids, lithium pilocarpine