Hi Evaluation of Anti-Ulcer Activity of Capsicum annuum Fruit Extract by Using Pylorus Ligation Model

V. Chinni Krishnaiah*¹, Chakka Gopinath¹, M. Praveen Kumar², B. Mohammed Ishaq^3
1Department of Pharmacology, Annamacharya College of Pharmacy, Rajampet, Kadapa Dist. A.P. India.
²Department of Pharmaceutics, Annamacharya College of Pharmacy, Rajampet, Kadapa Dist. A.P. India.
³Department of Pharmaceutical Analysis, Narayana Pharmacy College, Nellore, A.P. India.

A B S T R A C T
Many herbalists believe that Capsicum annuum (cayenne) is the most useful and valuable herb in the herb kingdom, not only for the entire digestive system, but also for the heart and circulatory system. Because it acts as a catalyst and it increases the effectiveness of other herbs when used along with them. Because of its ability to stimulate the circulatory and digestive systems, it has a tonic and antiseptic affect as well. The present study aims to evaluate the anti-ulcer activity of C. annuum chloroform extract. Anti-ulcer activity was evaluated by Pylorus ligation model (shay model) in rats (adult male albino; weighing 180 to 220 g). Changes in the gastric secretion volume, pH, Ulcer Index, Free acidity and Total acidity and Acid volume were observed in rats. C. annuumantagonized histaminic effects on gastric juice volume, pH and pepsin activities. Fraction also inhibited gastric ulcer formation induced by Pylorus ligation model in this study. The anti-ulcer effects of C. annuum found comparable to the Ranitidine, a reference anti-ulcer agent.
Keywords: Capsicum annuum, cayenne, chloroform, Anti-ulcer, Pylorus ligation, Ranitidine