V. Sreedhar*, Hindustan Abdul Ahad, B. Mohammed Ishaq, E. Sateesh Kumar, Shaik Muneer, Rukasana Hakeem
Balaji College of Pharmacy, Anantapur, AP, India–515001.
The objective of present study was evaluating the methanolic & chloroform extract anti-inflammatory activity of vitex trifoliate. Acute oral toxicity studies in mice of either sex (20-30 g) revealed that the extracts up to 2000 mg/kg have not produced any mortality in experimental animals. Since methanolic extracts have produced lower activity than chloroform extracts which almost equal active with standard drug, the chloroform extract was further subjected to phytochemical evaluation to isolate the pure molecules which are responsible for anti-inflammatory activity. The results were expressed as maximal paw oedema (maximal peak during the 6 h) and as total paw oedema (area under the time-course curve) and presented as mean ± s.e.m., n=5.
Keywords: Vitex trifoliate roots, Carrageenan, inflammation, ibuprofen, methanolic & chloroform extract.