Sunday , 19 May 2024

Enhancement of Solubility and Dissolution Rate of Nelfinavir Mesylate using Complexing Agents

M. Kiranmai1*, M. Divya1, G. Vijaya Reddy1, G. Kalpana Devi2
1Sai Pranavi College of Pharmacy, Keesara, R.R. Dist., Telangana, India
2Assistant Professor, Sai Pranavi College of Pharmacy, Keesara, R.R. Dist., Telangana, India

In the present work, an attempt has been made to develop improvement of bioavailability tablets of nelfinavir mesylate. In the present work to enhance the solubility and dissolution rate of selected drug molecule. All the formulations were prepared by direct compression method using 6mm punch on 8 station rotary tablet punching machine. The blend of all the formulations showed god flow properties such as angle of repose, bulk density, tapped density. The prepared tablets were shown good post compression parameters and they passed all the quality control evaluation parameters as per I.P limits. Among all the formulations, F1 formulation showed maximum % drug release i.e., 94.95% in 50 min hence it is considered as optimized formulation. The F1 formulation contains PEG 6000 as polymer in the concentration of 50 mg. 
Keywords: nelfinavir, PEG 4000, PEG 6000, bioavailabilityenhances.

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