Wednesday , 19 June 2024

Design and In-Vitro Evaluation of Enteric Coated Pulsatile drug delivery system of Zileuton Tablets

Kiran Kumar Yada1*, Dharmajit Pattanayak1, Saumya Das1, P. Nithin Kumar2
 1Associate Professor, Vikas college of pharmaceutical sciences, Rayanigudem, Suryapet.
2Research Assistant, KP Labs, Kothapet (A Division of KDPL), Hyderabad.

In the present research work pulsatile drug delivery system of Zileuton tablets were formulated by employing compression coating technology. Initially the core tablets were prepared by using various concentrations of super disintegrates, the formulated core tablets were coated with the polymers by using compression coating technology. All the  core  and  press  coated  tablet  formulations  were  subjected  to  various physical and chemical evaluation tests for core and press coated tablets. The thickness, hardness and weight variation shown by all the tablet formulations were found within the official pharmacopoeial limits.  In vitro release of Zileuton of core tablet formulations F1-F12, F4 showed faster drug release after 15 min. Faster drug release can be correlated with the high disintegration and friability observed in this study. The enteric-coated formulations C1, C3, and C4 showed maximum drug release after 4 hour. C2 formulation showed slow release about 10.64% in around 8 hour. C5 and C6 showed maximum drug release after 7th hr. Time dependent pulsatile drug delivery system has been achieved from tablet of formulation C5 and C6 with 102.79% and 100.21%.
Keywords: Zileuton, Super disintegrates, Ethyl cellulose, Pulsatile tablets.

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