Saturday , 20 April 2024

Discerning Sarcosine Biosensor in the Presence of Elevated Concentrations of Ascorbic Acid and Uric Acid

S. Brillians Revin*
Assistant Professor, Department of Chemistry (MSc., Ph.D, Post-doctoral Research Scientist-South Korea, 2012-2014), Francis Xavier Engineering College, Scad Group of Institutions,Tirunelveli, India.

The electrochemical response of Sarcosine (Sar) in the presence of elevated concentrations of Ascorbic acid (AA) and Uric acid (UA) is reported by differential pulse voltammetry (DPV) using an electro-polymerized film of 3-amino-5-mercapto-1,2,4-triazole on glassy carbon (p-AMTa) electrode for the first time. Bare glassy carbon (GC) electrode fails to show voltammetric signal for Sar. However, p-AMTa electrode shows a clear voltammetric signal for Sar at 0.96 V. Further, p-AMTa electrode separates the voltammetric signals of AA, UA and Sar in a mixture with the potential differences of 200 mV for AA-UA and 680 mV for UA-Sar. The selective determination of Sar even in the presence of 40-fold high concentrations of AA and UA was successfully demonstrated in this work.
Keywords: Polymer; Sarcosine; Biosensor; Ascorbic acid; Uric acid

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