Raviteja, N. SambaSiva Naik*, Gayathri, Sd.Fathima Zahera
Narasaraopet Institute of Pharmaceutical Sciences, Narasaraopet, Andhra Pradesh, India
The present research works discuss the development of a UV estimation method for febuxostat. Simple, fast, accurate and cost efficient and reproducible. Spectrophotometric method has been developed for the estimation of febuxostat in bulk and tablet formulations. The wave length (λ max) selected for the febuxostat was 315 nm. The linearity for this drug at the selected wavelength is lies between 0.2 to 1µg/ml.Beer’s law obeyed in this concentration range with correlation coefficient of 0.9999. The limit of detection and limit of quantification was found to be 1.0585 and 3.2077 µg/ml respectively. The validity of the described procedure was assessed. The proposed method was successfully applied to the determination of febuxostat in pharmaceutical formulations with out any interference from common excipients.
Key words: Febuxostat, Absorbance, Validation, Detection Limit