Friday , 19 July 2024

Development and Validation of UV Spectrophotometric Method of Febuxostat in Bulk and Tablet Formulations

About author
Raviteja, N. SambaSiva Naik*, Gayathri,  Sd.Fathima Zahera
Narasaraopet Institute of Pharmaceutical Sciences, Narasaraopet, Andhra Pradesh, India
E-mail: [email protected]

The present research works discuss the development of a UV estimation method for febuxostat. Simple, fast, accurate and cost efficient and reproducible. Spectrophotometric method has been developed for the estimation of febuxostat in bulk and tablet formulations. The wave length (λ max)   selected for the febuxostat was 315 nm. The linearity for this drug at the selected wavelength is lies between 0.2  to  1µg/ml.Beer’s law  obeyed in  this  concentration  range  with correlation coefficient  of  0.9999. The  limit  of  detection  and  limit of quantification  was found to be 1.0585  and 3.2077 µg/ml respectively. The validity of the described procedure was assessed. The proposed method was successfully applied to the determination of febuxostat in pharmaceutical formulations with out any interference from common excipients. 
Key words: Febuxostat, Absorbance, Validation, Detection Limit        

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