Chinmaya Keshari Sahoo*1, A. Amulya Reddy2, Vandana Kethavath2 and Prashanth Surabi2, Eshwar Mule2
*1Research Scholar, Osmania University College of Technology, Osmania University, Hyderabad, A.P.-500007
2Princeton College of pharmacy, korremula, Ghatkesar, Ranga Reddy Dist-500388
The aim of the current study was to design sustained release-based drug delivery system for Metformin hydrochloride (MS).The objective of the present work was to develop an oral sustained release Metformin hydrochloride tablet prepared by wet granulation method using hydrophilic hydroxyl propyl methylcellulose and Xanthan gum polymer as rate controlling factor. All the batches were evaluated for thickness, weight variation, hardness, and drug content uniformity and in vitro drug release. Hydrophilic matrix of HPMC alone could not control the Metformin release effectively for 12 hr whereas when combined with Xanthan gum could slow down the release of drug and can be successfully employed for formulating sustained-release matrix tablets.The dosage regimen of Metformin hydrocloride is 500mg tablet twice in a day. The drug eliminated in urine (about 90%) is in 24hrs with plasma elimination half lifeof 6.2 hrs. Hence Metformin hydrocloride was chosen as a model drug with an aim to develop a sustained release system for a period of 12 hrs.The sustained release tablet was prepared by wet granulation technique using controlled release polymer hydroxyl propyl methyl cellulose (HPMC) and using xanthum gum combindly for controlling release rate. The tablet formulation (MS5) containing 150mg of HPMCK100M and 25mg of Xanthum gum considered as overall best formulation (with an in vitro release of 97.86%).This sustained release system was found to deliver MS at a zero-order rate for 12 hrs. Short term stability study (at 40±2ºC/ 75±5% RH for three months) on the best formulation indicated that there no significant changes in drug content. IR spectroscopic study indicated that there are no drug excipient interactions.
Keywords: Sustained release, Metformin hydrochloride (MS), Xanthum gum, Zero order,IR