Friday , 24 May 2024

Analytical appraisement of some commercially available brands of Metformin Hydrochloride Tablet in Dhaka, Bangladesh

Zubair khalid Labu*1, Pradip Debnath1, Md. Samiul Basir1, Jalal Uddin1, Nabila Anjum1, Nadia sultana1, Sukdeb Biswas1, Krishanu Sikder2
1World University of Bangladesh (WUB), Bangladesh
2Gono University (GB)
*E-mail: [email protected]

Metformin hydrochloride contains metformin500mg, a medicine to treat diabetes. It belongs to a class of oral hypoglycemic agent called biguanide. It is the first-line drug of choice for the treatment of type-2 diabetes, particularly in overweight and obese people (International Diabetes Federation, Akinleye M.2012). There are several of metformin hydrochloride tablets available within the drug delivery system globally including Bangladesh. Availability of numerous brands of motormen tablets in Bangladesh drug market today places health practitioners in a dilemma of generic substitution. The objective of the study was to evaluate the physicochemical equivalence of seven brands of metformin hydrochloride tablets marketed in Bangladesh using in vitro tests. The physicochemical equivalence of seven brands Metformin hydrochloride tablet were assessed through the evaluation of  both official and non-official standards such as  uniformity of weight, friability, hardness, disintegration, assay and  dissolution rate.  All the brands complied with the official specifications.
Keywords: Metformin hydrochloride, type-2 diabetes physicochemical equivalence

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