Rakesh Jojo1, Arun Prasad1, B. K. Tiwary1, Subha Ganguly2*
1Department of Veterinary Microbiology, College of Veterinary Science & Animal Husbandry, Birsa Agricultural University, Kanke, Ranchi – 834 006, Jharkhand, India
2AICRP-PHT (ICAR), Department of Fish Processing Technology, Faculty of Fishery Sciences, West Bengal University of Animal and Fishery Sciences, 5, Budherhat Road, P.O. Panchasayar, Chakgaria, Kolkata -700 094, WB, India.
The present study was conducted to asses the immunomodulatory effect of feeding cow urine distillate (CUD) in comparison to a known positive immunomodulator, Levamisole HCl as feed additive on humoral and cell mediated immune response in broiler birds. For monitoring humoral immune response against NDV vaccine HI test was done. For monitoring cell mediated immune response status in all the four groups, contact sensitivity test using DNFB (2, 4-dinitrofluorobenzene) as contact sensitizer was used. On all weekly intervals post NDV vaccination, higher MHI antibody titer was observed in levamisole treated group than any other groups. There was significantly (p<0.01) higher MHI titer observed in the levamisole treated group T2 than T1 (CUD) treated group and two control groups at most ages post vaccination. The study indicated immunopotential effect of CUD but to a much lesser extent than levamisole, a proven immunostimulant and CUD can be recommended in broiler ration at optimum dose level against NDV.
Keywords: Antibody titer, Broiler, CUD, Immunomodulator, Levamisole.