Saturday , 13 August 2022

Comparative Study of Natural and Synthetic Superdisintegrants in the Formulation of Oral Disintegrating Tablets

Dr. R. Srinivasan, K. Vinod Kumar*, G. Lakshmana, D. Rajesh Kumar, M. Yedu Kondalu
Siddhartha Institute of Pharmaceutical Sciences, Jonnalagadda, Narsaraopet, Guntur, Andhra Pradesh, India.

A B S T R A C T
Orally disintegrating tablets (ODTs) are solid dosage forms containing medicinal substances which disintegrate rapidly, usually in a matter of seconds, when placed on the tongue. Super-disintegrants plays the major role in oro-dispersible tablet. Bambuterol Hcl oral disintegrating tablet was prepared by direct compression method with fifteen various formulations (F1 to F15).then the tablets were evaluated for  pre- compression studies include bulk density, tapped density, Carr’s index (or) % compressibility, Hausner ratio and Angle of repose. Evaluation studies include hardness, thickness, friability test, weight variation test wetting time, water absorption ratio, drug content estimation, disintegration test, In-vitro dissolution study  and stability Studies. The formulation (F5) containing 4% crospovidone gave the least disintegration time of about 10 sec among all formulations. It also released a maximum of 101% of drug within 30mins and hence the formulation (F5) was selected as the best formulation.
Keywords: Orally Disintegrating Tablets, Bambuterol HCl, Water absorption ratio and Crospovidone

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