Monday , 20 May 2024

Comparative Study of Natural and Synthetic Superdisintegrants in the Formulation of Oral Disintegrating Tablets

Dr. R. Srinivasan, K. Vinod Kumar*, G. Lakshmana, D. Rajesh Kumar, M. Yedu Kondalu
Siddhartha Institute of Pharmaceutical Sciences, Jonnalagadda, Narsaraopet, Guntur, Andhra Pradesh, India.

Orally disintegrating tablets (ODTs) are solid dosage forms containing medicinal substances which disintegrate rapidly, usually in a matter of seconds, when placed on the tongue. Super-disintegrants plays the major role in oro-dispersible tablet. Bambuterol Hcl oral disintegrating tablet was prepared by direct compression method with fifteen various formulations (F1 to F15).then the tablets were evaluated for  pre- compression studies include bulk density, tapped density, Carr’s index (or) % compressibility, Hausner ratio and Angle of repose. Evaluation studies include hardness, thickness, friability test, weight variation test wetting time, water absorption ratio, drug content estimation, disintegration test, In-vitro dissolution study  and stability Studies. The formulation (F5) containing 4% crospovidone gave the least disintegration time of about 10 sec among all formulations. It also released a maximum of 101% of drug within 30mins and hence the formulation (F5) was selected as the best formulation.
Keywords: Orally Disintegrating Tablets, Bambuterol HCl, Water absorption ratio and Crospovidone

Scroll To Top