Uday Sasi Kiran Kantheti*1, D. Yoganand Kumar2, Bhargav Ganinna3, P. Kedar Nath4
1,2,4Department of pharmacology, Royal college of pharmacy and health sciences, Berhampur, Odisha-760002,
3Department of Chemisrty, Lamar University, Beaumont, USA.
The present study was aimed to evaluate the anti-diabetic-activity potential of Casuarina equisetifolia leaves against streptozotocin (STZ) induced experimental rats. Ethanolic extract of bark of Casuarina equisetifolia(EECE) was administered to streptozotocin induced rats. Glibenclamide was used as a standard drug. Blood glucose levels were determined after oral administration of a dose of Casuarina equisetifolia (400 mg/kg b. wt) in diabetic groups. Blood glucose levels were determined on 0, 7th, 14th and 21st day after oral administration of ethanolic extracts of Casuarina equisetifolia (400mg/kg). An ethanolic extract of equisetifolia was found to reduce blood sugar in streptozotocin induced diabetic rats. Reduction in blood sugar could be seen from 7th day after continuous administration of the extract. The effect of extracts of Casuarina equisetifolia on serum lipid profile like Total cholesterol, triglycerides, low density, very low density and high density lipoprotein were also measured in the diabetic and non diabetic rats. There was significant reduction in Total cholesterol, LDL cholesterol, VLDL cholesterol and improvement in HDL cholesterol in diabetic rats. These results indicated that Casuarina equisetifolia possesses a hypoglycemic and antihyperlipidemic effect.
Keywords: Casuarina Equisetifolia, Antidiabetic, Antihyperlipidemic, Streptozocin Induced Rats