ANTIULCER ACTIVITY OF TERMINALIA CHEBULA IN PYLORIC LIGATURE INDUCED GASTRIC ULCERS

About author
Dimak Chand Sahu*, Anil Kumar Rai, Sanjay J. Ingle, Ravi Prakash
Department of Pharmacology SIRT, Bhopal, Madhya Pradesh, India
Malhotra College of Pharmacy, Bhopal, Madhya Pradesh, India
E-mail : [email protected]

ABSTRACT
Various factors that have been implicated in the pathogenesis of gastric ulcers are an increase in gastric acid secretion, pepsin activity and oxidative stress in the gastric mucosa, and a decrease in mucous and bicarbonate secretion. The poly herbal formulation of the many plants like Withania somnifera and Ocimum sanctum have been shown to exhibit anti-ulcer properties and are regular constituents in Ayurvedic Rasayana for the treatment of the same. Terminelia chebula is also known for its properties contributing to overall gastric care. So, all the individual constituents are well known for their anti-ulcer properties, on the basis of their different phytochemical constituents.

Key words: Antiulcers  Activity, Terminalia chebula,  Ayurvedic Rasayana, leukotrienes, endothelins