Senthil.J1*, Rameashkannan M.V1, Mani.P2, Jayaseelan.T3, Dinesh Kumar.G3
1Department of Medicinal Plant Biotechnology, Sharmila Institute of Medicinal Products Research Academy, Thanjavur, Tamilnadu, India.
2Department of Biotechnology, Annai College of Arts and Science, Kumbakonam, Tamilnadu, India.
3P.G and Research Development of Zoology and Biotechnology, A.V.V.M. Sri Pushpam College, Poondi,Thanjavur, Tamilnadu, India.
A B S T R A C T
Diabetes mellitus (DM) is a chronic metabolic disorder throughout the world which affects human body in terms of physical, psychological and social health. Traditional plants have been used for the treatment of diabetes mellitus. Hypoglycaemic agents from natural and synthetic sources are available for treatment of diabetes. Plants have been an important source of medicine with qualities for thousands of years. They are the basic source of knowledge of modern medicine. Medicinal plants have the capacity to produce a large number of phytochemical constituents with complex structural diversity that is known as secondary metabolites. Due to the traditional acceptability and availability of herbals, the management of type 2 diabetes is convenient with these herbal remedies of low costs and lesser side effects. Ipomoea is the largest genus in the flowering plant family Convolvulaceae with over 500 species. The genus occurs throughout the tropical and subtropical regions of the world and comprises annual and perennial herbs. The present study is to evaluate the antidiabetic activity of I.sepiaria ethanolic leaves extract against normal and Streptozotocin induced diabetic rats. Significant antidiabetic activity was exhibited by the herbal extract. Treatment with the herbal preparation 100 mg/kg body wt and 200 mg/kg body wt for 14 days in diabetic animals has shown significant decrease in blood glucose levels when compared to standard drug, Glibenclamide.
Keywords: I.sepiaria, Type 2 diabetes, Streptozotocin, Glibenclamide, Antidiabetic activity