S. Nageena1, P. Dharani Prasad2
1-2Department of Pharmacology, Krishna Teja Pharmacy College, Tirupati. Andhra Pradesh, India.
A B S T R A C T
Fungal diseases represent a critical problem to health and they are one of the main causes of morbidity and mortality worldwide. Human infections, particularly those involving the skin and mucosal surfaces, constitute a serious problem, especially in tropical and subtropical developing countries. Dermatophytoses are one of the most frequent skin diseases of human, pets and livestock. Pathogenic fungi, dermatophytes, have the ability to invade keratinized tissues of animals and humans and cause a disease, dermatophytosis, which is the commonest human contagious fungal disease. The present study aims to explore the antifungal activity of Ocimum sanctum on clinically isolated dermatophytic fungi. To know the phytoconstituents of Ocimum sanctum, the extracts were subjected to the analysis of macromolecules and secondary metabolites by using thin layer chromatography and high performance thin layer chromatography methods. The present study concluded that Ocimum sanctum leaf extracts showed both inhibitory and fungicidal activity against the dermatophytes studied. Secondary metabolites may be the reason for inhibition and fungicidal activity of this plant leaf extracts and fractions.
Keywords: Fungal diseases, dermatophytes, chromatography, fungicidal activity.