Friday , 14 June 2024

A Simple UV Spectroscopic Method for the Determination of Sertraline Hydrochloride in Bulk and Tablets

B. Gopi Krishna, A Maruthi, S. Muneer*, B. Mohammed Ishaq, H. Ruksana, Dr. Hindustan Abdul Ahad 
Department of Pharmaceutical Analysis, Balaji College of Pharmacy, Anantapur-515001, A. P, India
Received: 24 April 2014, Accepted: 6 June 2014, Published Online: 10 August 2014

A simple, economic, accurate UV method was developed for the estimation of Sertraline HCl (SRT) in bulk and tablet dosage form. Water was used as a diluent to dissolve SRT. The drug mixture was sonicated for 3 mins for the enhanced solubility. The absorptions were observed at 228.0 nm, which was selected for the further analysis of SRT in bulk and its tablet dosage forms. The proposed method was validated according to ICH guidelines. The method showed high sensitivity with linearity range from 5 to 30 μg/mL (r2=0.999) at 228.0 nm. The limit of detection (LOD) was found to be 1.22 and the limit of quantization (LOQ) was determined as the lowest concentration was found to be 4.08. The reports expressed that the proposed method was found to be simple, precise, accurate and rapid for the estimation of SRT in bulk and tablet dosage form using UV spectroscopy.
Keywords: Sertraline HCl, Distilled water, UV spectroscopy, ICH guidelines.

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