Tuesday , 11 May 2021

Formulation and In Vitro Evaluation of Oral Floating Tablets of Levofloxacin Hydrophilic Matrix

1Mohan kumar Atluri*1, K. Saravan kumar1, Jagadesh kumar Yadav kalluri1P. Sravan kumar2, Yagagowri1, P. Sravanthi3
Department pharmaceutics, Sree Vidyanikethan College Pharmacy, A. Rangampet, Tirupati, A.P, India-517102.
2Department pharmaceutics, Krishna Teja College of Pharmacy, Tirupati, A.P, India-517102.
3Department pharmaceutics, JNTUA OTRI, Anantapure, A.P, India
Received: 15 June2014, Accepted: 19 July 2014, Published Online: 10 August 2014

The present study was aimed at preparing a Floating drug delivery system for the model drug levofloxacin, and evaluating the various processing parameters including the buoyancy studies and in vitro drug release studies. Four formulations containing varying proportions of polymers like HPMC K4M and Ethyl cellulose and fixed amount of gas generating agent such as Sodium bicarbonate and hydrophobic meltable material like bees wax were prepared. The tablets were prepared by melt granulation technique and the prepared tablets remained buoyant for more than 7hrs in the release medium. The proportions of the polymers showed significant difference in the release of the drug. All the formulations exhibited diffusion dominant drug release and were found to be stable.
Keywords: Floating tablets, Buoyancy, Sustained release, levofloxacin

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