Sunday , 21 July 2024

A Review on Rosacea

K. Lavanyalahari*, C. Madhavilatha, P. Nagashirisha, P. Bhavana, D. Madava Teja, SK. Masheehabaanu
Ratnam Institute of Pharmacy, Pidathapolur, Nellore, A.P, India

Rosacea is a chronic inflammatory condition of the facial skin affecting the blood vessels and pilosebaceous units. Rosacea is more common in persons of northern and western European descent with a fair complexion, but it can affect skin of any color. Although symptoms may wax and wane during the short term, rosacea can progress with time. Patients usually present with complaints of flushing and blushing and sensitive skin, and their skin may be especially irritated by topical preparations. Rosacea has a variety of triggers; however, they may be unnoticed by the patient. Standard treatments approved by the FDA include azelaic acid, topical metronidazole, and oral tetracyclines, in particular minocycline and doxycycline. Other topical treatments include topical clindamycin, Sub antimicrobial-dose doxycycline, and sulfur products. Azithromycin and controlled-release minocycline are possible options for treating rosacea, but the FDA has not approved either agent for this indication.

Keywords: Rosacea, chronic condition, swollen bumps, skin condition, facial redness.


  • Holmes AD, Spoendlin J, Chien AL, Baldwin H, Chang ALS. Evidence-based update on rosacea comorbidities and their common physiologic pathways. J Am Acad Dermatol. 2018, 1(2): 78-81.
  • Thiboutot D, Anderson R, Cook-Bolden F, Draelos Z, Gallo RL, Granstein RD, Kang S, Macsai M, Gold LS, Tan J. Standard management options for rosacea: The 2019 update by the National Rosacea Society Expert Committee. J Am AcadDermatol. 2020, Jun 2(3): 90-97.
  • Rainer BM, Kang S, Chien AL. Rosacea: Epidemiology, pathogenesis, and treatment. Dermatoendocrinol. 2017, 3(4): 90-93.
  • Ahn CS, Huang WW. Rosacea Pathogenesis. DermatolClin. 2018, Apr 1(2): 87-90.
  • Rohrich RJ, Griffin JR, Adams WP., JrRhinophyma: Review and update. PlastReconstr Surg. 2002, 1(3): 80-84.
  • Scheinfeld NS. Rosacea.2006–194.Halder RM, Brooks HL, Callendar VD. Acne in ethnic skin.DermatolClin. 2003, 4(5): 45-50.
  • Berg M, Liden S. An epidemiological study of rosacea.1989, 2(3): 40-43.
  • Pray WS, Pray JJ. Differentiating between rosacea and acne.US Pharmacist.2004;3(4)(40-43).
  • Kroshinsky D, Glick SA. Pediatric rosacea. Dermatol Ther. 2006, 3(5): 56-60.
  • Shelley WB, Shelley ED. Advanced Dermatologic Therapy II. 2nd ed. Philadelphia: WB Saunders; 2001, 3(4): 70-72.
  • Berth-Jones J, Clark SM, Henderson CA. Rosacea and perioral dermatitis. In: Lebwohl M, Heymann WR, Berth-Jones J, et al., editors. Treatment of Skin Disease. London: Mosby; 2002, 2(3): 76-80.
  • Marks JG, Miller JJ, editors. Principles of Dermatology. 4th ed. Philadelphia: Elsevier/ Saunders, 2006, 1(2): 80-86.
  • Crawford GH, Pelle MT, James WD. Rosacea: I. Etiology, pathogenesis, and subtype classification. J Am Acad Dermatol. 2004, 2(3): 70-72.
  • Helm KF, Menz J, Gibson LE, Dicken CH. A clinical and histopathologic study of granulomatous rosacea. J Am Acad Dermatol. 1991, 2(3): 15-17.
  • Del Rosso JQ. Medical treatment of rosacea with emphasis on topical therapies. Exp Opin Pharmacother.2000,3(5): 56-60.
  • Norwood R, Norwood D. Treating rosacea. US Pharmacist. 2007, 4(5): 60-62.
  • Dressler-Carre M. Acne vulgaris and rosacea. In: Arcangelo VP, editor. Pharmacotherapeutics for Advanced Practice: A Practical Approach. Philadelphia: Lippincott Williams & Wilkins; 2005, 1(2): 53-55.
  • Van Zurren EJ, Graber MA, Hollis S, et al. Interventions for rosacea.Cochrane Database Syst Rev. 2005, 2(3): 23-26.
  • Pelle MT, Crawford GH, James WD. Rosacea II: Therapy. J Am AcadDermatol. 2000;1(2)(30-35).
  • Nally JB, Berson DS.Topical therapies for rosacea.J Drugs Dermatol. 2006, 7(8): 45-47.
  • ElewskiBE, Flesicher AB, Pariser DM. A comparison of 15% azelaic acid gel and 0.75% metronidzole gel in the topical treatment of papulopustular rosacea: Results of a randomized trial. Arch Dermatol.2003, 1(3): 58-60.
  • Colon LE, Johnson LA, Gottschalk RW. Cumulative irritation potential among metronidazole gel 1%, metronidazole gel 0.75%, and azelaic acid gel 15% 2007, 1(2): 60-63.
  • Madsen JT, Thormann J, Kerre S, et al. Allergic contact dermatitis to topical metronidazole: Three cases. Contact Dermatitis.2007;2(1)73-75.
  • Weissenbacher S, Merkl J, Hildebrandt B, et al. Pimecrolimus cream 1% for papulopustular rosacea: A randomized vehicle-controlled double-blind trial. Br J Dermatol.2007 1(2)45-48.
  • Chu CY. An open-label pilot study to evaluate the safety and efficacy of topically applied pimecrolimus cream for the treatment of steroid-induced rosacea-like eruption. JEur Acad Dermatol Venereol. 2007, 2(3)46-47.
  • Purnachandra reddy guntaka, Sriram N, Sarad Pawar Naik Bukke, Kiran Kumar Y , H. Parameshwar, Saravanan Jaganathan, Susmitha uppugalla. Formulation and Evaluation of Sustained Release Matrix Tablets of Glimipride Using Natural Polymers Tamarind Seed Mucilage and Guar Gum. Journal of Pharmaceutical Negative Results. 2022 Dec. 13: 5256-67. | Google Scholar | Abstract |
  • A Sivaranjini, Maya Ramteke, PK Senthilkumar, Alla Narayana Rao, D Phaneendra Pavan, A Gnanasekaran, N Sriram, Susmitha uppugalla. Antimicrobial Properties of Morinda Reticulata Gamble Extracts Against Antibiotic-Resistant Pathogenic Bacteria And Toxin Producing Molds. Journal of Pharmaceutical Negative Results, 2023 Jan. 1: 6633-9. | Google Scholar | Abstract |
  • Susmitha uppugalla , Chiranjib Bhattacharjee, Arunabha Mallik, N Sriram, G Sumithira, S Kameshwaran, S Sathya. Anticataleptic and Antiepileptic Activity of Ethanolic Extract of Leaves of Morinda Reticulate: A Study on Role of Dopaminergic System in Epilepsy in Albino Rats. Journal of Pharmaceutical Negative Results, 2022 Dec. 10: 4987-91. | Google Scholar | Abstract |
  • Koteswara Rao, P., Vikram Babu, B., Rama Krishna, A., Sushma Reddi, M., Sathish Mohan, B., Anjani Devi, K., Susmitha, U., Raghava  Rao. T, Green Synthesis of Silver Nanoparticles using Litsea glutinosa L. Leaves and Stem Extracts and their Antibacterial Efficacy, . Journal of Water and Environmental Nanotechnology, 2022, 7(4): 363-369. | Google Scholar | Abstract |
  • Susmitha Uppugalla , Kavitha Rajesh , Amareswarapu V Surendra , Kiran Kumar Y , Mohammed Gayasuddin , Sriram N , Prasad P Nadedkar. Effect of Pisonia Alba Root Extract on Cafeteria Diet-Induced Obesity in Rats. Journal of Pharmaceutical Negative Results. 2022 Dec. 1 3732-9. | Google Scholar | Abstract |
  • N Sriram, Susmitha Uppugalla , Kavitha Rajesh, S. Someshwara N , B Senthil Kumar, Prasad P Nadedkar, Shanta K Adiki. Cognitive Enhancing And Antioxidant Activity Of Ethyl Acetate Soluble Fraction of The Methanol Extract of Pisonia Alba Leaves In Scopolamine-Induced Amnesia. Journal of Pharmaceutical Negative Results. 2022 Dec. 1: 3740-9. | Google Scholar | Abstract |
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