A. Bharath kumar1*, C. Gopinath1, Sk. Karimulla2, Ramesh Dhani3
1Department of Pharmacy Practice, Annamacharya College of Pharmacy, Rajampet, A.P, India
2Department of Pharmacology, Dr. K.V. Subba Reddy Institute of Pharmacy, Kurnool, Andhra Pradesh, India
Department of Pharmaceutical Chemistry, Ratnam Institute of Pharmacy, SPSR Nellore, Andhra Pradesh, India-524346.
A B S T R A C T
It is a chronic inflammatory disorder of joints affects the diarthrodial joints and especially in the fingers, wrists, feet, and ankles. It is known as autoimmune disorder because it affects the immune system. The disease affects fourth and sixth decade of the life. The genetics, infections, vitamin-D deficiency in the bones, smoking has a significant role in progression of the disease. It is a systemic disorder affects the body. The B cells, T cells MHC cells activated when the immune system is days regulated. The symptoms include morning stiffness, rheumatoid nodules formation, systemic arthritis, pain in the fingers, wrists, feet, and ankles extra articular lesions formation cardio myopathy, bone marrow depression, pleural effusion. The diagnosis of the disease includes the presence of rheumatoid factor in the blood. Elevated Erythrocyte sedimentation rate, C reactive proteins rate, blood test, X rays of hand reveals the disease progression. The management of disease includes disease modifying Anti Rheumatoid Drugs, Interleukin antagonist, anti TNF agents, Non-steroidal anti-inflammatory drugs.
Keywords: Arthritis, Disease, Genetics, Immune System.