Department of Pharmaceutics, Maharishi Arvind Institute of Pharmacy, Jaipur-302020, Rajasthan, India
A well designed controlled drug delivery system can overcome some of the problems of conventional therapy and enhance the therapeutic efficacy of drug. There are various approaches in delivering a drug to the target site in a controlled release fashion. Microspheres are characteristically free flowing powders consisting of proteins or synthetic polymers which are biodegradable in nature and ideally having a particle size less than 200 µm. Microspheric drug delivery system has gained enormous attention due to its wide range of application as it covers targeting the drug to particular site to imaging and helping the diagnostic features. Microspheres also has advantage over other dosage forms like aerosol dosage form are used for local delivery of drugs for lungs disease but it has disadvantage of shorter duration of action. So microspheres can be used for sustained release and reducing side effects and hence to achieve better patient compliance. It also has advantage over liposomes, as it is physicochemically more stable. Microspheres are of micron size so they can easily fit into various capillary beds which are also having micron size. It is the reliable means to deliver the drug to the target site with specificity and to maintain the desired concentration at the site of interest without untoward effects. Microsphere is not only for prolonged release, but also for targeting of anticancer drugs to the tumour.
Key words: Microspheres, Novel drug delivery, Therapeutic efficacy, Target site