Denish kariya*, Kailash pancholi, Ranmal varu
E-mail: [email protected]
Synthesis and organic movement of new derivatives of 4-hydroxy Coumarin (4a-g) was achieved 7,8-dimethyl 4 hydroxy coumarin, secondary amine, Solution of formaldehyde and s solution of HCl used with heating for 8-10 hours. Reaction mass was cooled to room temperature, poured on to crushed ice and neutralized. Obtained solid was filtered and was with methanol to give pure product. It were supported by FTIR, NMR and mass spectra data.
Key words: 4-hydroxy Coumarins, 7,8-dimethyl 4 hydroxy coumarin, secondary amine and formaldehyde condensation synthesis.
Coumarin, the parent molecule of coumarin derivatives, is the simplest compound of a large class of naturally occurring phenolic substances made of fused benzene and a-pyrone rings. A lot of coumarins have been identified from natural sources, especially green plants. The pharmacological and biochemical properties and therapeutic applications of simple coumarins depend upon the pattern of substitution. Coumarins have attracted intense interest in recent years because of their diverse pharmacological properties. Coumarin derivatives have been shown to possess a remarkably broad spectrum of biological activity including antibacterial, antifungal, anticoagulant, anti-inflammatory, antitumor and anti-HIV activity. In addition, these compounds are used as additives in food and cosmetics, dispersed fluorescent brightening agents and as dyes for tuning lasers. Main representatives of the class are the hydroxyl derivatives, 4- and 7-hydroxycoumarins, also biologically active and very important for the synthesis of other coumarin derivatives.