Wednesday , 23 August 2017

Protective Effect of Aqueous Extract of Bauhinia Purpurea Flower in Doxorubicin Induced Cardiomyopathy in Albino Wister Rats

Md. Sultan Ali, K. Suresh*, Y. Suresh, Vijaya Lakshmi
Safa College of Pharmacy, Kurnool, Andhra Pradesh, India-518218

A B S T R A C T
The present study was undertaken to evaluate the cardio protective activity of Bauhinia purpurea family Fabaceae.  Aqueous extract of flower of Bauhinia purpurea Linn.  Were prepared successively. Preliminary Phytochemical studies revealed the presence of chemical constituents such as Saponins, flavonoids, Tannins and Proteins in aqueous extract.          The experiment was started with the treatment of Aqueous extract of Bauhinia purpurea flower by oral route in a dose of 10mg/kg, 20mg/kg, 30mg/kg, 40mg/kg and 50mg/kg of body weight to all groups for 7 days.  On 8th day animals were treated with doxorubicin 10mg/kg was administrated to all groups. After 72hrs of Doxorubicin induction the rats was fasted for 18hrs and anaesthetized with Thiopentone sodium 30mg/kg.  The blood was collected by cardiac puncture.  The heart was dissected out, washed immediately in Ice-chilled physiological saline, blotted and weighed.  Serum was separated from blood by centrifugation at 10,000 rpm for 20min.  Serum samples were used for various biochemical parameters. Cardio protective activity produced in aqueous extract of Bauhinia purpurea flower decreases the level of Infarct size, SGOT, SGPT and CK-MB.
Keywords: Cardioprotectivity, Flavonoids, Bauhinia purpurea, Doxorubicin.

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