Monday , 21 October 2019

Formulation and Evaluation of Nanocrystals to Improve Oral Bioavailability

Pratyusha Tatipamula1*, Dr. M. Sunitha2
1Research Scholar, Department of Pharmaceutics, JNTU Hyderabad, Telangana, India.
2Principal, Shadan Women’s College of Pharmacy, Khairatabad, Hyderabad, Telangana, India

A  B  S  T  R A C T
The development of nanocrystal-based drug formulations has yielded the opportunities to address and treat challenging diseases. Nanocrystals vary in size but are generally ranging from 100 to 500 nm. Through the manipulation of size, surface characteristics and material used, the nanocrystal can be developed into smart systems, encasing therapeutic and imaging agents as well as bearing stealth property. Further, these systems can deliver drug to specific tissues and provide controlled release therapy. This targeted and sustained drug delivery decreases the drug related toxicity and increase patient’s compliance with less frequent dosing. Nanotechnology has proven beneficial in the treatment of cancer, AIDS and many other disease, also providing advancement in diagnostic testing. In the presant work selected anti viral drugs Asunaprevir  and evaluated
Keywords: Drug delivery, nanocrystals, pharmaceuticals.

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