Wednesday , 2 December 2020

Formulation and Evaluation of Microsponge Loaded Hydrogel for Topical Delivery

Dangar Parul K1, Vidya Sabale1, Makwana Rajeshree P2
1Parul Institute of Pharmacy and Research, Limda, Vadodara-391760.
2B.Pharmacy college Rampura, Kakanpur, Panchamahal-389713

Background: The present investigation deals with the formulation and characterization of microsponge loaded hydrogel for topical delivery. Materials and Methods: Eudragit RS 100 and Ethyl cellulose was used as a polymer and polyvinyl alcohol was used as a cross-linking agent. Microsponge containing oxiconazole was prepared by quasi emulsion diffusion method using Eudragit RS100 and ethyl cellulose. All the microsponge formulations were evaluated for production and loading efficiency, drug content, SEM, FTIR studies and in vitro release studies. Gel preparation and characterization studies diffusion studies, viscosity, skin irritation tests are conducted. Results: The result of a 32 full factorial design revealed that the concentration of ethyl cellulose and concentration of PVA significantly affected on the dependent variables like particle size, loading efficiency and drug content of the batch F5 containing 1000mg ethyl cellulose and 0.5% PVA produced microsponge with particle size 48.69±0.505, loading efficiency 76.4±0.754 and drug content was 76.4±0.212.The optimized microsponge formulations conveniently incorporated into carbopol gel with uniform drug content. It was evaluated for viscosity, spread ability, drug release. The gel containing 1.5 % carbopol 940 give viscosity 1000±0.365 cps, spread ability 12.08±0.080 and drug release at 12 h 91.163% and pH was 6.82±0.004. Conclusion: In conclusion, microsponge loaded hydrogel was successfully formulated to control the action of the drug.
Keywords: Microsponge, Hydrogel, Quasi emulsion

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