Sunday , 4 December 2022

Synthesis Charecterization and biological evaluation of 4-amino-N’-(thiazol-2-yl) benzohydrazide

*S. Murali Krishna, Y. Padmalatha, L.K. Ravindranath, S. Chandrakala
Department of Chemistry, Sri Krishnadevaraya University, Anantapur, Andhra Pradesh, India.

A B S T R A C T
Synthesis of mannish bases derivatives containing aromatic rings were synthesized by the condensation 4-aminobenzohydrazide (1) with KSCN. It forms 2-(4-aminobenzoyl) hydrazine carbothioamide (3). The Compound (3) is treatment with substituted alpha halo ketones to obtained 4-amino-N’-(thiazol-2-yl) benzohydrazide (4). The structure of these newly synthesized compounds were characterized by 1H   NMR, 13CNMR , Mass, IR, and elemental analysis.
Keywords: KSCN, DMF, Hydrazine Hydrate, Alpha Halo Ketones

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