Synthesis and Spectroscopic Investigation of Imminent Bioactivity in the Cardanol Based Tetradentate CU (II), CO (II), ZR (IV), TH (IV) Complexes

Seema. A¹, IsacSobana Raj. C.^2*
1Research Scholar, Dept. of Chemistry and Research, N.M Christian College, Marthandam- 629165, India
²Department of Chemistry and Research, N.M Christian College, Marthandam-629165,Affiliated by M.S.U, Abishekapatti. Tirunelveli, Tamilnadu, India

A B S T R A C T
Cardanol Schiff bases derived synthetic compounds are an important class of ligands that were coordinate to metal ions and have been studied extensively. Considering the importance of metal complexes in the development of medical science four different Schiff base metal complexes such as Cu(II), Co(II), Zr(IV), Th(IV) were synthesized with the DFMPMNA ligand comprises of di-α-formylmethoxy-bis (3-pentadecenyl phenyl) methane i.e. DFMPMand 2-nitroaniline. The current experimental compounds were characterized by molar conductance, UV-Vis, IR, ¹HNMR, ¹³C NMR, XRD. Furthermore, the synthesized experimental complexes have been screened for invitro antibacterial as well as antifungal activity on microorganisms such as Proteus mirabillus, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa and fungi like Aspergillusflavus, Aspergillusniger, Rhizopus species, by well diffusion technique using DMF as the solvent. The invitro anticancer activities were tested for HeLa cancer cell lines using MTT assay. Hence, the present result was concluded that the Cu(II) complex contains a superior bacterial and fungicidal activity against the experimental pathogens and Zr(IV)complex possessed remarkable anticancer activity against theHeLa cell lines.
Keywords: DFMPM,2-nitro aniline, DFMPMNA, Schiff base, microbial activity, in-vitro anticancer activities