Sunday , 3 March 2024

Review on Alkaloidal and Non Alkaloidal Natural Products of Antimalarial Drugs

Jeyaraman Amutha, Iswarya Devi1*, Mathavan.P2, Jesan.K.J3
Department of Pharmaceutical Chemistry Arulmigu Kalasalingam College of Pharmacy, Anand Nagar, Krishnan kovil-626126.

Malaria is most dangerous parasitic infectious disease in many countries. Plasmodium falciparum which infects red blood cells(RBC).This disease is getting worse, mainly due to the increase resistance of Plasmodium falciparum against the widely available antimalarial drugs. Natural products have played a important role in the discovery of leads for the development of drugs to treat human diseases .The new antimalarial drugs may certainly emerge from plant sources. This review contains most of the recently published alkaloidal and non alkaloidal natural compounds from plants with antiplasmodial and antimalarial properties; non alkaloidal compounds belong under the classes of terpenes, limonoids, flavonoids, chromones, xanthones, anthraquinones and related compounds. Alkaloidal compounds belong to the classes of aminoquinolines, quimolinomethanol derivatives, diaminopyrimidines, sulphonamides, biguanides. Consider many antimalarial activities observe for all crude extracts and natural compounds are described here, by continuing investigation of plants used in traditional medicines for the treatment of malaria and they will lead the scientific discovery of more new efficient drug molecules and phytomedicines for this disease.

Keywords: malaria, alkaloidal products, non-alkaloidal products, Plasmodium falciparum, anti-malarial activity

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