Recent advances in the local drug delivery systems for improvement of anti-cancer therapy

Shaik. Afrin*, P. Venugopalah, Lokku. Chandupriya, M.P. Anitha, K. Vareesha
Ratnam Institute of Pharmacy, Pidthapolur (V), Muthukur (M), Nellore (Dt), Andhra Pradesh–524343, India.

 A B S T R A C T
The conventional anticancer chemotherapies not only cause serious toxic effects but also produce resistance in tumour cells exposed to long-term therapy. During the last few decades, scientists have been exploring new anticancer drug delivery systems such as nanoparticle-Based drug delivery, liposomes and hydrogels, Targeted drug conjugates to improve bioavailability, reduce drug-dose requirement, decrease multiple drug resistance, and save normal cells as non-specific targets. Hopefully, the development of novel drug delivery vehicles (nanotubes, liposomes, supramolecules, hydrogels, and micelles) will assist in delivering drug molecules at the specific target site and reduce undesirable side effects of anticancer therapies in humans. Nanoparticles and lipid formulations are also designed to deliver a small drug payload at the desired tumour cell sites for their anticancer actions. This review will focus on the recent advances in drug delivery systems and their application in treating different cancer types in humans.
Keywords: Southeast Asian countries, ASEAN, veterinary use, GHTF, AMDD