B. Venkateswara Reddy*, P. Sandeep, K. Navaneetha, P. Ujwala
Department of Pharmaceutics, St.Pauls College of Pharmacy, Turakayamjal(V), Hayath Nagar (M), Ranga Reddy Dist-501510, A.P, India
Pulsatile drug delivery systems are attaining more and more interest in modern pharmaceuticals for the development of drugs for which conventional drugs with continuous release are not deal. In some instances where constant blood level of drugs is not desirable, in such cases pulsatile drug delivery system is advisable. These are designed such a way that complete and rapid drug release is achieved after lag time. Pulsatile drug delivery systems are classified into site specific where the drug releases at desired site within intestinal tract. Time controlled release in which drug release is controlled by the delivery system and not by the external environment. Site controlled release in which the drug release is controlled pH, or enzymes present in the intestinal tract. This review covers various pulsatile systems like capsular systems, osmotic systems, single and multiple systems based on use of soluble and erodible polymers coating and the current PDDS already available in the market.
Keywords: Pulsatile drug delivery systems, Single unit, Multiple units.