Gangadhar D*, Naresh Gorantla, Hindustan Abdul Ahad, Rajesh Pavan
PG Department of Pharmaceutics, Balaji College of Pharmacy, Ananthapuramu, Andhra Pradesh, India
APOTHEKE-2014, 8 Nov 2014, Organized by Balaji College of Pharmacy, Ananthapuramu, Andhra Pradesh, India
Ornidazole is an anti-microbial drug used to treat dental and mouth diseases like Bad breath, tooth decease, oral cancer, mouth sores, tooth erosion, gingivitis and periodontitis are the teeth and mouth problem which are mainly due to the microbial infections. In the present study, an injectable controlled drug delivery system of Ornidazole gel implants were prepared by using natural biodegradable polymers like chitosan, Xanthan gum and Locust bean gum in different concentrations. All the formulated gels were subjected to various evaluation parameters such as compatibility study by TLC, surface pH, viscosity, drug content, in vitro release studies and antimicrobial susceptibility test and found good results. The in vitro release of the prepared gels showed an initial bursting followed by narrowed release. The first order, Higuchi and Kerseymeres Peppas plots were plotted. These results indicate that the release followed a zero order or first order kinetics. Hence we conclude the formulated dental gels of the antimicrobial agent Ornidazole is a promising dosage form for the treatment of various dental infections.
Keywords: Periodontitis, Injectability, Release Kinetics and Dental Gels.