B. Mohammed Ishaq*1, C. Hari Kumar2, B. Kishore Kumar reddy3, Hindustan Abdul Ahad1, Shaik Muneer1, Rukasana Hakeem1, E. Sateesh Kumar1
1Balaji College of Pharmacy, Anantapur, AP. India 515001.
2Department of Pharmacology, Vasavi College of Pharmacy, Bhkarapeta, Kadapa Dist. AP. India
3Department of Pharmacology, Sri Kirshnadevaraya University, Anantapur, AP. India 515001.
Rosa centifolia Linn belong to the family Rosaceae is an erect shrub 1 to 2 meter in height. Flowers of the plant are large, showy and colorful. This plant is not explored still now, but traditionally it is used in treatment of diabetes, conjunctivitis. The present investigation was carried out to evaluate the cardiotonic activities of Rosa centifolia flowers. Dried flower extracts of Rosa centifolia was extracted with petroleum ether, chloroform, ethanol, methanol and water using soxhlet apparatus. Present study was carried out to determine the cardiotonic activity by using infusion of heartwood with different dilutions & compared with cardiotonic activity of digoxin‐the lifesaving cardiotonic. The activity was tested by using isolated frog heart assembly. The preliminary phytochemical investigation of dried flowers showed presence of terpenoids, flavnoids, glycosides, steroids and phenolic compounds. From the above extracts, ethanolic extract showed significant cardiotonic activity. So, it was further subjected to thin-layer and column chromatographic studies. Later the residue was analysed by using U.V. and I.R. spectroscopy for characterization. The results of phytochemical investigation had led to the conclusion that the compound may be terpenoid derivative. The present preliminary studies confirm the better cardiotonic activity of Rosa centifolia than digoxin. Further studies can confirm the reduced toxicity & this will be the advantage of Rosa centifolia over digitalis. Thus, in future it will be interesting to isolate the active chemical constituents which were responsible for the cardiotonic activity.
Keywords: Cardiotonic activity, Digoxin, Rosa centifolia, Isolated frog heart.