Tuesday , 11 May 2021

Pharmacodynamic Drug Interaction of Anti-Hypertensive Drug Combination Metoprolol and Telmisartan on Combined Anti-diabetic Effect of Glimepiride and Metformin in Normal and Streptozotocin Induced Diabetic Rats

B. Kishore Kumar Reddy1*, K. Mohan1, C. Hari Kumar2, Dr. Hindustan Abdul Ahad3B. Mohammed Ishaq3 
1PG Department of Pharmacology, College of Pharmaceutical Sciences, Sri Krishnadevaraya University, Anantapur–515001, A.P. India.
2Department of Pharmacology, Vasavi College of Pharmacy, Bhakarapeta, Kadapa, A.P. India.
3Balaji College of Pharmacy, Anantapur–515001, A.P. India.

Polytherapy is a useful tool for treating coexistent diseases, but drug combination may reduce efficacy and/or favor the appearance of adverse reactions with different degrees of severity. A Combination of Metoprolol [MTP] with Telmisartan [TLS] are commonly used in the treatment of hypertension in diabetic patient under the therapy of Glimepiride [GLP] and Metformin [MTF]. Literature showed that risk of retinopathy and cardiovascular disease are more in diabetic hypertensive patients, which may cause morbidity and mortality. Therefore present study is aimed to investigate the safety, reliability of Combination of Metoprolol with Telmisartan on the combined anti-diabetic effect of Glimepiride and Metformin and possible drug interaction with the later combination when they were administered as combination treatment. The study was conducted on healthy and streptozotocin induced diabetic rats. The hypoglycemic effects of Combination of Metoprolol with Telmisartan alone and in combination were tested. The results obtained shows that Metoprolol with Telmisartan combination repeated dose treatment has influence the blood glucose levels in healthy and diabetic rats. They have hypoglycemic property. Therefore it was further suggested that readjustment of dose and frequency of administration of oral anti-diabetic agents may be made when they are used simultaneously with Metoprolol and Telmisartan.
Keywords: Metoprolol, telmisartan, antidiabetic, glimepride, metformin, streptozotocin, antihypertensive.

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