Saturday , 25 May 2024


Narendra Singh Sisodiya*, Gajendra Singh Rathore, Dharmendra Singh Sisodiya, Avinash Nigam
Bhupal Nobles’ College of Pharmacy, Udaipur , Rajasthan, India.
E-mail: [email protected], [email protected]

Now day’s formulation research is breaking barriers of conventional methods. Today, active ingredients can be delivered with a level of convenience, performance and bioavailability never seen in the market place. Fast disintegrating or Mouth dissolving tablet (ODTs) is one such novel approach to increase consumer acceptance by virtue of rapid disintegration, self administration without water or chewing. This novel type of delivery system offers convenience for treatment-resistant population who have difficulty in swallowing unit oral dosage form, namely Tablets and Capsules. These formulations are particularly beneficial to pediatric and geriatric patients. It is estimated that 50 % of the population is affected by dysphagia which results in high incidence of non-compliance and ineffective therapy. The aim of this article is to review the ideal properties, significance, characteristics, limitation, choice of drug candidates, challenges in formulation, approaches for preparation of ODTs, Patented technologies on ODTs, Suitable drug candidates for ODTs, and Evaluation tests of ODTs.
Key words: Orodispersible, tablets, delivery system, technologies, orally, compression.
Oral drug administration has been one of the most suitable and widely accepted by the patients for the delivery of most therapeutically accepted drug. Various dosage forms like tablet, capsule and liquid preparations have been administered by oral route. But, due to some unsuitable physiological conditions of gastro intestinal tract like relative poor absorption, presence of various digestive enzymes in gastro-intestinal lumen and epithelium, poor absorption efflux(i.e. by p-glycoprotein) and first pass metabolism by hepatic enzymes, the administration of some drug is affected. Also, it limits many drugs to reach into the therapeutic level. Hence to minimize the problems associated with drug absorption through gastro intestinal membrane, researchers have been developing intra oral drug delivery system that will enhance drug level, avoid first pass and gut wall metabolism, increases the bioavailability of active medicament or improve convenience of dosing.

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