Thursday , 23 May 2024

Oral Matrix Formulation for Floating drug Delivery System to Increase Gastric Retention time

Amit Saini Singh*1, Dr. S.N. Sri Harsha2, D. Yashwanth Kumar3, K.S.S.N. Neelima4B. Poornima5
Department of Pharmacy, NIMS University, Jaipur
PACIFIC University, Udaipur, Rajasthan
Sri Krishnachaitanya College of pharmacy, Hyderabad

Abstract: All the pharmaceutical products formulated for systemic delivery via the oral route of administration, irrespective of the mode of delivery (immediate, sustained or controlled release) and the design of dosage form (solid dispersion or liquid), must be developed within the intrinsic characteristics of GI physiology. The recent scientific and patented literature concluded that an increased interest in novel dosage forms which retained in the stomach for prolong and predictable period of time has been shown. It is a well known fact that differences in gastric physiology, such as, gastric pH and motility exhibit both intra as well as inters- subject variability demonstrating significant impact on gastric retention time and drug delivery behavior. Several approaches are currently utilized in the prolongation of the GRT including floating drug delivary systems, swelling and expanding systems, polymeric bio adhesive systems, high density systems, modified shape systems and other delayed gastric emptying devices. Floating dosage forms are emerging promising dosage forms. Floating dosage form can be prepared as tablets, capsules by adding suitable ingredients as well as by adding gas generating agent. In this review various techniques used in floating dosage forms along with current & recent development of stomach specific floating drug delivery system for gastro retention discussed.
Key words: Floating Drug Delivery system, Drug Delivery system Acyclovir, Gastro Retentive, Floating Dosage forms

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