Thursday , 29 July 2021

One Pot Synthesis and Biological Activities of Schiff Base

P. Venkateswara Rao, A.V. G.S. Prasad*1, P.S.S. Prasad *2
1Department of Chemistry, Nizam College (Autonomous), Hyderabad, Telangana, India.
2Drug Control Administration, Hyderabad, Telangana, India.

A B S T R A C T
In the present study an intermolecular reductive Schiff base formation from nitroarene and benzaldehyde to yield diarylimine is carried out in the presence of iron powder and ammonium chloride. In the present study new Schiff base compound derived from 2- nitro 4, 6-dimethylpyridine with Indole-3-carboxaldehyde. The ligand and metal complexes have been screened for their microbiological activity. The experimental results suggest that Schiff base and metal complex ligands are more potent in anti-bacterial activities
Keywords: Tandem reaction, intermolecular reduction, green chemistry, Antibacterial activity, Antifungal activity

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