1Deepak. M. Nagrik*, 2Shrikant S. Patil, 2Rameshwar S. Dhamak
1Department of Chemistry, G.S. College, Khamgaon, M.S., India-444303
2Department of Chemical Technology SGB Amravati University, Amravati, M.S., India-444602
Multicomponent reactions (MCRs) are emerged as one of the most imperative synthesis route in organic synthesis due to their wide application range in pharmaceutical chemistry. A variety of β-acetamido ketones were readily prepared in good to excellent yield (90.-95%) via four component reaction of aromatic aldehydes, enolizable ketones, acetonitrile, acetyl chloride in presence of mix metal oxide CuO-SnO2 as versatile catalyst. The corresponding compounds were obtained in good to excellent yield, under mild conditions and ambient temperature.
Keywords: β-acetamidoketones, Multicomponent synthesis, Enolizable ketones, CuO-SnO2