V. Sravani*1, Dr. P. Venkatesh2, K. Sowjanya3
1-3Jagans Institute of Pharmaceutical Sciences, Jangala Kandriga, Nellore, A.P.
A B S T R A C T
Antibiotics are manufactured at an estimated scale of about 100,000 tons annually worldwide, and their use had a profound impact on the life of bacteria on earth. More strains of pathogens have become antibiotic resistant, and some have become resistant to many antibiotics and chemotherapeutic agents, the phenomenon of multidrug resistance. The methicillin-resistant staphylococcus aureus which is resistant to methicillin but usually also to aminoglycosides, macrolides, tetracycline, chloramphenicol, and lincosamides. Such strains are also resistant to disinfectants and MRSA can act as a major source of hospital-acquired infections. An old antibiotic, vancomycin, was resurrected for treatment of MRSA infections. However, transferable resistance to vancomycin is now quite common in Enterococcus and found its way finally to MRSA in 2002, although such strains are still rare. Microbes that are causative agents of infectious disease represent a serious public health concern globally. The invention and use of antibiotics have been one in all the main scientific achievements of the 20th century. Antibiotics are either cytotoxic to the microorganisms, permitting the body’s natural defenses, like the immune system, to flush them out. A strict following of antibiotic guidelines can prevent the development of antibiotic resistance in the community.
Keywords: Antibiotics, resistance, cytotoxic, microorganisms, immune system.