Thursday , 29 February 2024

Investigation of Leonotis Nepetifolia for its Antioxidant and Anti Steroidogenic Properties in Male Rats

Musale Jayesh Vasudeo1, I. Sarath Chandiran*2, P.D. Chaudhari3 
1Research Scholar, PRIST University, Thanjavur, Tamilnadu, India.
2Professor, Ratnam Institute of Pharmacy, Pidathapolur, SPSR Nellore-524346, Andhra Pradesh, India.
3Principal, Modern College of Pharmacy, Nigdi, Pune.44, Maharashtra, India.

The objective of the present study is to explore anti-steroidogenic and antioxidant properties of ethanolic extract of whole plant of Leonotis nepetifolia (EELN). The different dose of ethanolic extract  were given by gavage to rats in the In Vivo test at a dose of 100, 200, 300mg/kg of body weight to rats in group II, II & III respectively, along with control dose. At the end of study various parameter such as lipid profile and anti-oxidant level in the testicular tissue were analyzed. Finding of this study explored a significantly increase (p<0.05) the total cholesterol and triglycerides levels, LDL and VLDL cholesterol in EELN treated rats when compared to control. But HDL cholesterol and anti-oxidant levels were significantly decreased in EELN treated rats in dose dependent manner and also we observed the role of Leonotis nepetifolia on antioxidant defense mechanism in rat testis. The present study, concluded that ethanolic extract of Leonotis nepetifolia capable to suppress the fertility in male rats without altering general metabolism.
Keywords: Anti steroidogenic, antioxidant, Leonotis nepetifolia

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