Tuesday , 24 May 2022

Insilico Drug Activities of Some Isatin Metal Complexes

ABOUT AUTHOR
A. Anto Arockia Raj1*, J.Vinnarasi1, M.Johnson2
1Department of Chemistry, St.Xavier’s College, Palayamkottai-627002, Tamil Nadu, India.
2Centre for Plant Biotechnology, Dept. of Botany, St.Xavier’s College, Palayamkottai-627002, Tamil Nadu, India.
*E-mail:antset.anto@gmail.com

Abstract
Isatin schiff bases complexes were found to have anti-HIV activity. Hence our aim is to correlate the biological activity of isatin complexes against the HIV by Insilico method. The target molecule (virus) was taken from Protein data bank. Various softwares were used to find out the drug likeness properties of these schiff bases. We have selected Maraviroc, Darunavir, Nelfinavir, Zidovudine and Zalcitabine as standard drugs among the available drugs for correlating the drug activities against our Isatin transition metal complexes. We observed that some of our complexes were found to have higher drug activities compared to standard drugs.
Keywords. Isatin complexes, Hex 6.3, Marvin sketch, ACD /I Lab.

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