Inhibition of FGFR2 signal transduction in Acne Vulgaris using Bioactive Flavonoids: An Insilico approach

Kannan Ramaraj, Alexander Ronaldo Anuf*
Department of Biotechnology, Kamaraj College of Engineering and Technology, Virudhunagar.
NCADDD, 25 July 2014, Organized by Department of Pharmaceutical Technology, Anna University, BIT Campus, Tiruchirappalli–620024, Tamil Nadu, India

Abstract
Acne vulgaris is a common, chronic inflammatory disease, which was androgen-induced sebum production, altered keratinisation, inflammation and bacterial colonization of the sebaceous follicle that primarily affects the face, chest, and back by Propionibacterium acnes. The study aims at finding leads from phyotocompounds to target the protein involved in the growth factor of acne vulgaris. The fibroblast growth factor receptor 2 (FGFR2) is a receptor for fibroblast growth factor which involved in the signaling of skin appendage formation, pilosebaceous follicle homeostasis, comedogenesis, sebaceous gland proliferation and lipogenesis. The FGFR2-gain-of-function mutations in Apert syndrome and unilateral acneform nevus are most helpful model diseases pointing the way to androgen-dependent dermal- epithelial FGFR2-signaling in acne. Docking analysis was carried out for the above target with the selected bioactive flavonoids and the efficiency was compared with the synthetic drug ‘PD 1373074’ using Molegro docking software. The flavanoid compound Hesperidin showed higher docking scores with the FGFR2 receptor.
Keywords: fibroblast growth factor receptor 2, Hesperidin, Molegro, flavonoids