Kadiri Sunil kumar1*, Avanapu Srinivasa Rao2
1Vijaya College of Pharmacy, Munaganoor-501511, Hyderabad, A.P, India
2Bhaskar Pharmacy College, Yenkapally, Moinabad, R.R Dist, A.P, Hyderabad- 500075
*E-mail: [email protected]
Safi is an herbal medicine and is said to be used as a blood purifier1. The study was designed to investigate the anti-ulcer effect of chloroform extract of Chrozophora plicata leaves (600mg/kg) an essential herb in unani medicine Safiagainst ethanol induced gastric ulcer model in albino rats. In the present study, anti-ulcer activity was assessed by using ethanol (1 ml/200 g of 99.80% p.o) induced Ulcer models in albino rats. The gastroprotective activity was determined by comparing gastric volume, acidity, ulcer score and ulcer index in control, test extract and standard (ranitidine 10mg/kg) treated rats. An ulcer index of 1.66 ± 0.42 has been observed in chrozophora plicata treated rats, whereas standard ranitidine (10mg/kg) treated rats exhibited an ulcer index of 1.41 ± 0.30. Both extract treated and standard ranitidine treated rats has shown ulcer indices which are less than the ulcer index in control rats i.e 5.66 ± 0.80.The percentage protection of ulcers was found to be 70.67 with chloroform extract of chrozophora plicata and with standard ranitidine a percentage protection of 75.04 has been obtained. It is evident from literature that Chrozophora plicata leaves possess flavonoids3. The results obtained indicate that Chrozophora plicata possesses ulcer protective principles and flavonoids may be responsible for gastroprotective activity4.
Key words: Chrozophora plicata, Flavonoids, gastroprotective activity