Gastroprotective Activity of Plant Chrozophora Plicata an Essential Herb in Unani Medicine Safi

ABOUT AUTHOR
Kadiri Sunil kumar^1*, Avanapu Srinivasa Rao^2
1Vijaya College of Pharmacy, Munaganoor-501511, Hyderabad, A.P, India
²Bhaskar Pharmacy College, Yenkapally, Moinabad, R.R Dist, A.P, Hyderabad- 500075
*E-mail: [email protected]

Abstract
Safi is an herbal medicine and is said to be used as a blood purifier¹. The study was designed to investigate the anti-ulcer effect of chloroform extract of Chrozophora plicata leaves (600mg/kg) an essential herb in unani medicine Safiagainst ethanol induced gastric ulcer model in albino rats. In the present study, anti-ulcer activity was assessed by using ethanol (1 ml/200 g of 99.80% p.o) induced Ulcer models in albino rats. The gastroprotective activity was determined by comparing gastric volume, acidity, ulcer score and ulcer index in control, test extract and standard (ranitidine 10mg/kg) treated rats. An ulcer index of 1.66 ± 0.42 has been observed in chrozophora plicata treated rats, whereas standard ranitidine (10mg/kg) treated rats exhibited an ulcer index of 1.41 ± 0.30. Both extract treated and standard ranitidine treated rats has shown ulcer indices which are less than the ulcer index in control rats i.e 5.66 ± 0.80.The percentage protection of ulcers was found to be 70.67 with chloroform extract of chrozophora plicata and with standard ranitidine a percentage protection of 75.04 has been obtained. It is evident from literature that Chrozophora plicata leaves possess flavonoids³. The results obtained indicate that Chrozophora plicata possesses ulcer protective principles and flavonoids may be responsible for gastroprotective activity⁴.
Key words: Chrozophora plicata, Flavonoids, gastroprotective activity