Formulation, Development and In-Vitro studies of Sotalol – Gastro Retentive Floating tablets

K. Jacob Isaac*, Bh. Sri Swetha, D. Raghava, K. Nageswara Rao
Department of Pharmaceutical Technology, K.G.R.L College of Pharmacy, Bhimavaram-534201, Andhra Pradesh, India

A B S T R A C T
In the “present research work gastro retentive floating matrix formulation of Sotalol” by “using various hydrophilic polymers. “Among all the formulations” the formulations prepared by using Xanthan gum were “unable to produce desired drug release, they were unable to” retard “drug release up to 12” hours. The formulations prepared with Methocel K15 M  retarded the drug “release up to 12 hours” in the concentration of  75 mg (ST3).The “formulations prepared with xanthan gum” were “unable to retarded the drug “release for more than 12 hours. Hence they were not considered”.
Keywords: Sotalol, Guar gum, Xanthum gum, HPMC K15 M and Floating tablets