Formulation Development and In-Vitro Evaluation of Metoprolol Succinate Sustained Release Tablets

Pericharla Venkata Hari Priya*, Bhogireddi Sriswetha, D. Raghava, K. Nagesawara Rao
Department of Pharmaceutical Technology, K.G.R.L College of Pharmacy, Bhimavaram-534201, A.P, India

A b s t r a c t
Metoprolol succinate is a cardio selective β-blocker used in the management of secondary hypertension complications. Metoprolol succinate is prescribed to suppress the hypertension condition and to minimize the cardiac related disorder. In the present study, metoprolol succinate sustained-release tablets were successfully prepared by the wet granulation method. HPMC and ethyl cellulose were used as drug release modifying polymers in varying ratios. All developed tablets were passed the uniformity of weight, friability, uniformity of thickness, and uniformity of diameter test respectively. The crushing strength of formulated tablet was in ranges of 1.2 to 2.6 and showed the optimum tensile strength. The formulated tablet’s percentage of drug content and content of uniformity had 98.50 and 99.12.The formulated batch F2 capable for provide the desirable drug release up to 20 hours period. The stability study shows the formulation batch F2 was stable. Therefore, this formulation method is economically it may be suitable for the pharmaceutical industries to use this type of simple technology for the development of advanced formulations
Keywords: Metoprolol succinate, HPMC, Ethyl cellulose, Sustained release tablet, Matrix tablet