Wednesday , 19 June 2024

Formulation Design and In-vitro Characterization of Proliposomal Drug Delivery System of Cytarabine

Gopala Krishna Tadakamalla*1, K. Someshwar2, P. Nithin Kumar1, Vagdevi. Y1
1Research Assistant, KP Labs, Kothapet (A Division of KDPL), Hyderabad
2Manager, Formulation R&D, KP Labs (A Division of KDPL), Kothapet, Hyderabad

Abstract
The present work involves the use of novel drug delivery system, i.e., oral proliposomal powder for improving the oral delivery of the drug Cytarabine. Short half-life of Cytarabine (4 to 6 hr) indicates the need of controlled release delivery. The objective of this work is to enhance the oral delivery of Cytarabine from the proliposomal powder formulation. Cytarabine is a non-selective beta blocker/alpha-1 blocker used in the treatment of mild to severe congestive heart failure (CHF) and high blood pressure. In the present study proliposomal powder formulations of Cytarabine were prepared by slurry method. Formulations comprising various ratios of span 20, 40, 60 and 80 and cholesterol with various combinations were prepared. The developed proliposomal formulations were evaluated for flow properties, % entrapment, in vitro dissolution, solid state characterization (DSC, XRD, SEM, and FTIR) studies. The flow properties of all the developed formulations were within the limits, In-vitro dissolution release of Optimized formulation upto 10hrs showed highest entrapment 89.12% of Cytarabine among all formulations. Entrapment efficiency of optimized formulation was observed 89.84% respectively. The optimized formulation proved to be an excellent carrier system for enhancing oral delivery of Cytarabine. 
Keywords: Cytarabine, Span 20, Span 40, Span 60, Span 80, Proliposomes, Maltodextrin. 

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