Thursday , 20 June 2024

Formulation and Statistical optimization of Esomeprazole Non-Effervescent Gastric Floating Matrix Tablets

Madhavi Latha S*,  Ramesh Babu J1
*Research Scholar, Acharya Nagarjuna Univer
1Professor, Chebrolu Hanumaiah College of Pharmaceutical Sciences, Andhra Pradesh, India

Esomeprazole is a proton pump inhibitor that decreases the amount of acid produced in the stomach. Esomeprazole is used to treat symptoms of gastro esophageal reflux disease and other conditions involving Zollinger-Ellison syndrome in adults. In the present work, two methods of preparations were employed i.e. direct compression of physical mixtures and compression of melt granules obtained from hot fusion technique. Lactose was employed as channeling agent to study the effect on drug release. In each method, 32 full factorial design was employed for design and optimization of Esomeprazole non-effervescent gastric floating matrix tablets (NEGFMT) with an amount of Glyceryl Laurate (X1) and percent of Lactose (X2) as independent variables. Y1(%DR1) and Y2(T100) were selected as dependant variables. Among the two methods of preparation of NEGFMT, melt granulation technique was found to be more useful compared to physical mixture due to intimate distribution of drug in the Glyceryl Laurate. Though both the optimized formulations met the theoretical release profile, the concentration of GL in the melt granulation was found to be less than half required for physical mixture.
Keywords: Esomeprazole, Glyceryl laurate, Lactose, Non-gas generating floating tablets.

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