Friday , 21 June 2024

Formulation and In-vitro, In-vivo evaluation of Periodontal Films containing Metronidazole and Minocycline HCl

D.K. Borole1*, S.N. Sriharsha1, Yashwant Kumar.D1, K.S.S.N. Neelima2 
1Pacific College of Pharmacy, Pacific University (PAHER), Udaipur, India
2SARC- (Scientific and Applied Research Centre) – Hyderabad

Local delivery devices are designed to deliver the drug locally into periodontal pocket. Metronidazole is a nitroimidazole used to treat protozoal infections. Solvent casting technique was used for the preparation of periodontal films using chloroform and dichloromethane in (1:1) mixture using hydroxypropyl cellulose (HPC), hydroxypropylmethyl cellulose K4M (HPMC K4M), polymethyl methacrylate (PMMA1, 20,000) in chloroform and dichloromethane (1:1) mixture, dibutylphthalate (10% v/w of that of polymer), glycerol (20%v/v) as plasticizers and Eudragit L-100 as polymer. FTIR and UV spectroscopic methods revealed no interaction between Metronidazole and polymers. These films are evaluated for thickness, Folding endurance, texture analysis, tensile strength, drug content, mucoadeshion stability studies and biodegradable ability. Data of In vitro release of films reveals that F1 formulation has maximum drug release. In-vitro anti bacterial activity and in vivo studies also performed for all the formulations. From the study we can conclude that formulation F1 has good stability and best formulation for further study.
Keywords:  Metronidazole, periodontal films, local delivery, in-vitro release, in- vitro anti bacterial activity, in-vivo evaluation.

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