Srigaddhe Vijaykumar2, Ramesh Kannuri2, Gampa Vijaykumar1
1Professor and Head, Dept. of Pharmacy, KGR Institute of Technology and Management, Rampally, Kesara, Rangareddy, Telangana, India.
2KGR Institute of Technology and Management, Rampally, Kesara, Rangareddy, Telangana, India.
A B S T R A C T
The aim of the present study was to develop sustained release formulation of Trapidil to maintain constant therapeutic levels of the drug for over 12 hrs. Various natural polymers such as Guar gum, karaya gum and xanthan gum were employed as polymers. Trapidil dose was fixed as 1.5 mg. Total weight of the tablet was considered as 300 mg. Polymers were used in the concentration of 50 mg,75mg and 100 mg concentration. All the formulations were passed various physicochemical evaluation parameters and they were found to be within limits. Whereas from the dissolution studies it was evident that the formulation (F7) showed better and desired drug release pattern i.e.,98.51 % in 12 hours. It followed zero order release kinetics mechanism.
Keywords: Trapidil, sustained release, Guar gum, karaya gum and xanthan gum