Monday , 26 February 2024

Formulation and In-Vitro Evaluation of Ropinirole Sustained Release Tablets

MD. Kathiza Begum*, Bh. Sri Swetha, D. Raghava, K. Nageswara Rao, L. Kalyan
Department of Pharmaceutical Technology, K.G.R.L College of Pharmacy, Bhimavaram-534201, Andhra Pradesh, India

A b s t r a c t
Ropinirole is a medication used to treat Parkinson’s disease (PD) and restless legs syndrome. In PD the dose needs to be adjusted to the effect and treatment should not be suddenly stopped. It is taken by mouth. The aim of the present study was to develop sustained release formulation of Ropinirole Hydrochloride to maintain constant therapeutic levels of the drug for over 12hrs. Various natural polymers such as Guar gum, karaya gum and locustbean gum were employed as polymers. Ropinirole Hydrochloride dose was fixed as 5 mg. Total weight of the tablet was considered as 60 mg. Polymers were used in the concentration of 10mg, 15mg and 20mg concentration. All the formulations were passed various physicochemical evaluation parameters and they were found to be within limits. Whereas from the dissolution studies it was evident that the formulation (F6) showed better and desired drug release pattern i.e.,97.35 % in 12 hours. It followed zero order release kinetics mechanism.

Keywords: Ropinirole Hydrochloride, Guargum, gum karaya and locust bean gum, sustained release tablets

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