Formulation and In-vitro Evaluation of Ergotamine Tablets for Buccoadhesive Drug Delivery System

Gampa Vijaya Kumar¹, Dr. G.S. Valluri², Thota Karunakar^3
1Professor and Head, Department of Pharmacy, KGR Institute of Technology and Management, Rampally, Kesara, Rangareddy, Telangana, India.
²Professor, KGR Institute of Technology and Management, Kesara, Rangareddy, Telangana, India.
³KGR Institute of Technology and Management, Rampally, Kesara, Rangareddy, Telangana, India.

ABSTRACT
Ergotamine was formulated as buccal tablets to improve its bioavailability by avoiding first pass metabolism. HPMC K4M, HPMC K15M, HPMC K100M were selected as polymers various formulations were prepared by using these polymers. The formulations prepared with HPMC K100M in the concentration of 8mg (F8) was showing 92.06% drug release.
Key words: Ergotamine, Buccal tablets, HPMC K4M