Y. Krishna Reddy*, T. Lavanya, T. Pulliah, T. Nagendra, T. Soundarya, Praveen kumar
Bomma Institute of Pharmacy, Khammam, Telangana, India
A B S T R A C T
The aim of the present study was to develop effervescent floating tablets of Voriconazole to maintain constant therapeutic levels of the drug for over 12 hrs. Various grades of polymethacrylate polymers and ethyl cellulose were employed as polymers. Voriconazole dose was fixed as 4 mg. Total weight of the tablet was considered as 250 mg. Polymers were used in the concentration of 25, 50 and 75 mg concentration. All the nine formulation containing sodium CMC, Chitosan & Guar gum in different concentration are prepared floating tablets. All the formulations were passed various physicochemical evaluation parameters and they were found to be within limits. The weight variation ranges from 248.3 to 259.4. The hardness of a effervescent floating tablets of voriconazole ranges form 4.1 kg/cm2 to 4.5 kg/cm2. The friability its loss their weight upto 0.45 % to 0.56%. The thickness of floating tablet ranges form 4.5 mm to 4.9 mm. The Drug content of a voriconazole ranges from 98.42% to 99.87%. The buoyancy time of floating tablet ranges form 4.0 min to 4.7. Whereas from the dissolution studies it was evident that the formulation F6 showed better and desired drug release pattern i.e., 96.33 % in 12 hours. It followed zero order release kinetics mechanism.
Keywords: Voriconazole, Eudragit RL 100, Eudragit RS 100, Ethyl cellulose, Sustained release tablets.